WebThe severe consequences of the Zika virus (ZIKV) infections resulting in congenital Zika syndrome in infants and the autoimmune Guillain–Barre syndrome in adults warrant the development of safe and efficacious vaccines and therapeutics. Currently, there are no approved treatment options for ZIKV infection. Herein, we describe the development of a … WebJan 5, 2024 · Spikes and nanoparticles. The spike protein from SARS-CoV-2 is quite large, so scientists often formulate abridged versions that are simpler to make and easier to use.
Nanoparticle vaccine for COVID-19 EurekAlert!
WebMay 9, 2024 · A Spike-ferritin nanoparticle (SpFN) vaccine elicited neutralizing titers more than 20-fold higher than convalescent donor serum, following a single immunization, while RBD-Ferritin nanoparticle (RFN) immunogens elicited similar responses after two immunizations. Passive transfer of IgG purified from SpFN- or RFN-immunized mice … WebJan 8, 2024 · The researchers spliced spike protein and ferritin DNA together and then expressed the hybrid protein in cultured mammalian cells. The ferritin self-assembled into … fidelis medicaid log in
SARS-COV-2-Spike-Ferritin-Nanoparticle (SpFN) Vaccine …
WebAug 28, 2024 · Ferritin is an attractive nanoparticle platform for production of vaccines and ferritin-based vaccines have been investigated in humans in two separate clinical trials. We confirmed proper folding and antigenicity of spike on the surface of ferritin by cryo-EM and binding to conformation-specific monoclonal antibodies. WebDec 22, 2024 · by Dennis Thompson The U.S. Army says it has developed a COVID-19 vaccine it believes could work against any and all coronavirus variants, including Omicron. … WebDec 22, 2024 · The shot is currently named Spike Ferritin Nanoparticle Covid-19 vaccine, or SpFN. It has been developed by scientists at the Walter Reed Army Institute of Research (WRAIR), who are seeking... fidelis medicaid managed care dental