WebbTaken on January 21, 2006 . All rights reserved . About; Jobs; Blog; Developers; Guidelines; Privacy; Terms; Help; Report abuse; Help forum; English WebbFurther, we identified the MYC proto-oncogene protein as a second CPSF1 substrate and show that active ABL kinase protects MYC from CPSF1-mediated degradation. These studies uncover a role for CPSF1 in cancer pathobiology as an E3-ligase antagonizing the expression of the oncogenic transcription factors, HIF-1α and MYC.
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