Rbm38 hif1
WebJan 1, 2024 · Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor, which comprises alpha (HIF1α) and beta (HIF1β) subunits [1, 2].The alpha subunits of HIF in mammalian cells are encoded by HIF1A, EPAS1/HIF2A, and HIF3A. HIF1β is encoded by ARNT1 and ARNT2 [3,4,5].HIF1 is considered a major target of HIF-mediated hypoxia … WebAlternative Name: HIF1; HIF-1A; HIF1A; HIF-1-alpha; HIF1-alpha; BHLHE78; MOP1; PASD8 Reactivity: Human (QC Testing) Isotype: Mouse IgG1, κ Immunogen: Human HIF-1α aa. 610-727 Application: Western blot (Routinely Tested), Immunofluorescence (Tested During Development) ...
Rbm38 hif1
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WebScienceDirect.com Science, health and medical journals, full text ... WebDec 15, 2014 · But too much p53 suppresses cell-cycle progression, causing cell death, premature aging and even cancer." The relationship between p53 and Rbm38 can best be described as a loop: p53 regulates ...
WebApr 17, 2024 · Increased expression of the HIF1 targets Adm, Vegf, Glut1, Pdk1, and Egl-9 family hypoxia-inducible factor 1 (Egln1) in rod ΔVhl and rod ΔVhl;Hif2a mice verified that HIF1 was transcriptionally ... WebJan 1, 2015 · Hypoxia-inducible factor 1 (HIF1), a heterodimeric transcription factor, consists of HIF1α and HIF1β and is necessary for cell growth and survival under a hypoxic …
WebNov 23, 2024 · Objective The study is to research how miR-34-SIRT1 is regulated during hypoxia in lung cancer cells. Results Analysis of publicly available datasets from patients … WebMar 14, 2024 · Rbm38, an RNA-binding protein, has been implicated in cell-cycle regulation and differentiation ().Consistent with its cellular activities, Rbm38 is necessary for normal hematopoiesis and loss of Rbm38 leads to accelerated aging and spontaneous tumors in mice ().The diverse biological functions of Rbm38 are probably due to its role as an RNA …
WebDiscovery. The HIF transcriptional complex was discovered in 1995 by Gregg L. Semenza and postdoctoral fellow Guang Wang. In 2016, William Kaelin Jr., Peter J. Ratcliffe and Gregg L. Semenza were presented the Lasker Award for their work in elucidating the role of HIF-1 in oxygen sensing and its role in surviving low oxygen conditions. In 2024, the same three …
WebHypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA-binding protein and a p53 family target, via mRNA translation Seong-Jun Cho 1 ... HIF1 alpha (HIF1α) and HIF1β … lithium ion closet lightWebJul 8, 2024 · RBM38 is located on chromosome 20q13.31 and is highly expressed in a variety of human tissues (RPKM > 4 in 19 of 27 tissues; Fig. 1).Comparative phylogenic … lithium ion conductionWebFeb 15, 2024 · The p63 transcription factor, a p53 family protein, regulates genes involved in various cellular processes, including cell growth and differentiation. We previously showed that RNA-binding motif protein (Rbm38) is a p63 target and, in turn, regulates p63α mRNA stability by binding to the AU/U-rich e … impurity\\u0027s jwWebBioGRID Interaction 2470505 Between RBM38 And HIF1A. Toggle navigation. Bio GRID 4.4 impurity\\u0027s jxWebThe possibility of targeting and integrating RBM38 and LXR-α as a therapeutic approach against car-diac remodeling has never been investigated. Herein, we provide evidence to support that RBM38 is a potential modulator of myocardial hypertrophy via the LXR-α-Dependent lipogenesis pathway. impurity\\u0027s k1Webfrom publication: Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 family target, ... (HIF1), a heterodimeric transcription factor, ... impurity\u0027s jzWebApr 1, 2024 · Interestingly, RBM38 is unique in that it can either suppress or enhance p53 mRNA translation via altered interaction with eIF4E potentially mediated by serine-195 (S195) in RBM38. Thus, multiple RBM38/eIF4E knock-in (KI) cell lines were generated to investigate the significance of eIF4E-RBM38 interaction in controlling p53 activity. impurity\u0027s jy