Phenotypically modulated
Web29. júl 2024 · Europe PMC is an archive of life sciences journal literature. WebConsistent with this, knockdown of RBPJ in phenotypically modulated human aortic SMC enhanced endogenous SMC marker gene expression, an effect likely mediated by …
Phenotypically modulated
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Web14. okt 2004 · Abstract. A hallmark of smooth muscle cell (SMC) phenotypic switching in atherosclerotic lesions is suppression of SMC differentiation marker gene expression. Yet … Web1. nov 2000 · One characteristic feature of phenotypically modulated VSMCs is that they express markedly lower levels of proteins (differentiation marker proteins) required for the VSMCs’ normal, differentiated function, including smooth muscle α-actin (SMαA), smooth muscle myosin heavy chain (SMMHC), and SM22α (5 – 7). Given that phenotypic ...
WebHuman articular chondrocytes modulated away from their original phenotype by serial subcultures in monolayer differentially express mRNAs for endopeptidases. The mRNAs … Web13. nov 2015 · Thomas Durcan is a member of the Neurodegenerative Disease research group at the Montreal Neurological Institute-Hospital (The Neuro). His research focuses on using patient-derived stem cells to develop standardized discovery assays and 3D mini-brain models for neurodegenerative and neurodevelopmental disorders. Dr.
WebDifferences in muscle transcriptome among pigs phenotypically extreme for fatty acid composition: Autor: Puig-Oliveras, A.; ... Thus, our results indicate that the lipid metabolism of FAs is differently modulated when the FA composition in muscle differs. For instance, a high content of PUFA may reduce FA and glucose uptake resulting in an ... Web22. okt 2024 · To determine whether the dysfunction of the LXRα-ABCA1 axis is common in phenotypically modulated VSMCs, we performed the proteomic analysis of the contractile …
Web5. nov 2024 · KLF4 factors are expressed in phenotypically modulated SMCs and bind to G/C-rich cis elements found in SMC marker gene promoters. KLF4 is not expressed in differentiated SMCs in normal blood vessels but is rapidly induced following vascular injury . The effects of KLF4 in suppressing SMC differentiation marker gene expression are …
WebThe focus of this study is on goldsinny wrasse (Ctenolabrus rupestris), a small marine fish inhabiting coastal waters of the north-eastern Atlantic. This species is caught in large numbers to serve as cleaner fish in salmonid aquaculture. We genotyped 2073 goldsinny wrasse from 43 sites along the Scandinavian coastline with 143 SNPs. intersec meaningWeb29. júl 2024 · Phenotypically modulated SMCs have previously been noted to express markers associated with myofibroblasts ( Acta2 ), mesenchymal stem cells ( Sca1) and … intersec middle eastWeb12. sep 2024 · Recent studies demonstrated that phenotypically modulated ECs are one of the prominent cell types within atherosclerotic lesions, and they are involved in the regulation of extracellular matrix (ECM) production, inflammatory cytokine secretion, and plaque stability. [ 1, 2] In vivo EC lineage-tracing studies in mice demonstrate that ≈45% of … new fall hair color trendsWebPhenotypically, ΔCT behaves as a Hairless gain of function allele in several developmental contexts, indicating that the conserved CT domain of H has an attenuator role under native biological contexts. Using several independent methods to assay protein-protein interactions, this study defined the sequences of the CT domain that are involved ... new fall inn englewood innWebGenome editing holds tremendous promise for preventing, ameliorating, or even curing disease, but a thorough discussion of its bioethical and social implications is necessary to protect humankind against harm, a central tenet of the original Hippocratic Oath. It is therefore essential that medical students, physicians, and all health care workers have a … intersec mwとはWe tested the hypothesis that phenotypically modulated smooth … new falling sand gameWeb25. feb 2015 · In intimal lesions, we observed 2 phenotypically distinct subtypes of SMCs: hyperchromatic and oval cells staining positive for αSMA, vimentin, SM1 and HHF35 but … intersec mw マニュアル