WebbKainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE. However, whether KA activates KA receptors (KARs) as an agonist to mediate the … WebbKainate receptor agonists AMPA, α -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; GluR, glutamate receptor. Table 2. Kainate receptor antagonists AMPAR, α -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione; GluR, glutamate receptor.

Excitatory synapse pathway - Abcam

WebbPrototypic kainate receptor agonist. 1 ml water soluble pack. CAS Number: 487-79-6 ; Purity: > 99% ; Soluble in 1ml of water to give specified mM/ml concentration; Form / … WebbKainic acid monohydrate (2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine); >= 99% TLC; Kainic acid is used to study mechanisms of excitation-induced apoptosis and epilepsy; Kainic acid is an agonist for kainate-class ionotropic glutamate receptors; This compound is also offered as part of Sigma& mbx apothecary

Presynaptic kainate receptor-mediated bidirectional modulatory …

WebbSelective GluK1 kainate receptor antagonist (IC 50 = 0.46 µM). ... Kainic acid. Price from $121. Add to Wish List Add to Compare. CNQX disodium salt. ... Prototypic, selective kainate receptor agonist. Potent excitant and neurotoxin. Find out more. Shopping Tools. Product guides; Promotions; Kainate receptors, or kainic acid receptors (KARs), are ionotropic receptors that respond to the neurotransmitter glutamate. They were first identified as a distinct receptor type through their selective activation by the agonist kainate, a drug first isolated from the algae Digenea simplex. They have been traditionally classified as a non-NMDA-type receptor, along with the AMPA receptor. KARs are less … WebbKainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC 50 = 0.6 - 7.4 μM) and a partial agonist at AMPA receptors (EC 50 = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. mbw wisconsin