WebFor dissolution rate-limited absorption (DCS IIa), the formulation strategy involves increasing dissolution rate enhancements. Dissolution rate is often accelerated by increasing … Webin turn allows for DCS II composites to be divided into DCSII and DCSIIb composites (15). DCS IIa composites are dissolution limited and hence expression strategies to ameliorate exposure would concentrate on flyspeck size reduction similar as Nano milling and micronization, whereas DCS IIb composites are solubility limited and

API Solubility and Dissolution Enhancement Via Formulation

WebMar 9, 2024 · The two most common reasons for poor bioavailability for compounds in this quadrant are slow dissolution rate (DCS IIa) and low solubility (DCS IIb). These two causes constitute around 50%-70% of poorly bioavailable compounds. Additionally, some 10%-20% of the compounds are poorly permeable. WebDCS classification of NCE Case study •US Biotech wanted to determine the DCS (Developability Classification System) designation for their small molecule Background … making whoopee dr john

The Developability Classification System for Poorly …

WebMay 12, 2024 · For DCS Class IIa molecules, which have low solubility but high permeability, are limited by the dissolution rate rather than by their fundamental solubility itself. Poloxamer excipients present a simple and powerful formulation approach that can enhance dissolution rate and hence bioavailability while minimizing resource requirements. WebAug 7, 2024 · This important subdivision of DCS is useful in guiding the formulator to the right type of drug delivery technology. For Class IIa, simple particle size reduction or solutions are a great fit. For class IIb, a lipid-based solution or amorphous solid dispersion might be more suitable. WebNov 2, 2024 · The DCS introduced two new compound categories: dissolution limited (DCS IIa) and solubility limited (DCS IIb). For DCS IIa molecules, particle size reduction and … making whoopee michelle pfeiffer