WebJul 23, 2024 · The interaction between colchicine and statins as well as colchicine and clarithromycin, can lead to colchicine toxicity which can cause rhabdomyolysis, especially if the patient is renally impaired. 73,74 Amlodipine is considered a mild CYP3A4 inhibitor which can cause 30% increase in simvastatin acid exposure. 75 Also, amlodipine is ... WebOct 10, 2011 · One of the unique properties of simvastatin is very low bioavailability (<5%) due to high firstpass metabolism. For example, if a 20-mg dose is administered, only 1 mg reaches the systemic circulation. Increasing the bioavailability to 50% with a CYP3A4 inhibitor will increase the systemic exposure by 10-fold, to 10 mg.
ZOCOR (simvastatin) Tablets - Food and Drug Administration
WebObjective: To investigate the effects of CYP3A4 substrates or inhibitors, simvastatin (substrate), diltiazem (moderate inhibitor), and ketoconazole (strong inhibitor) on the pharmacokinetics and safety of saxagliptin, a CYP3A4/5 substrate; and the effects of saxagliptin on these agents in three separate studies. WebAug 5, 2011 · HMG CoA reductase inhibitors (statins) are prone to interaction with antiretrovirals as a result of metabolism through CYP3A4 and CYP2C19 and inhibition of hepatic uptake by the OATP1B1 transporter [2,109]. Protease inhibitors can induce dyslipidemia or augment existing dyslipidemia, resulting in the need for antilipidemic … five star restaurants in georgia
Frequency and clinical relevance of drug interactions with
WebThe inhibition of CYP2D6, CYP2C19 and CYP3A4 was tested in a cocktail study following 12 day dosing of fluoxetine. At day 12 the average plasma concentrations were: (R)-fluoxetine 280±90 nM, (S)-fluoxetine 770±270 nM, (R)-norfluoxetine 200±70 nM and (S)-norfluoxetine 320±110 nM (Supplemental Figure 1).After 12 days, fluoxetine … WebSimvastatin is not an inhibitor of CYP3A4 and is not expected to affect the plasma levels of other drugs metabolized by CYP3A4. Coadministration of simvastatin (40 mg QD for … WebResults: In total, 245 co-prescriptions of CYP3A4 inhibitors with simvastatin (134 events) or atorvastatin (111) were detected. Diltiazem (86 events), verapamil (72), … five star restaurants in indianapolis