Ctgf and liver fibrosis
WebHepatic fibrosis, which has characteristics of excessive deposition of extra cellular matrix (ECM), occurs by various chronic liver injuries, such as from chemicals, viral infection, and alcoholic or nonalcoholic hepatic steatosis [].Although the pathogenesis of hepatic fibrosis is not revealed clearly, hepatic stellate cells (HSCs) are believed to be a major role in the … WebMar 20, 2024 · Fibrosis, MMP-9, and TIMP-1 expressions in hEnSCs. (a) Cell viability of hEnSCs as determined in response to varying concentrations of CDDP. (b) Expressions of Collagen I, Collagen III, CTGF, Fibronectin, α-SMA, MMP-9, and TIMP-1 in hEnSCs within each group. A representative blot from one of the three independent experiments …
Ctgf and liver fibrosis
Did you know?
WebDec 5, 2024 · Liver fibrosis was induced through IP injection of CCl 4 (0.5 µl/g body weight) twice a week for six weeks the Ccn2/Ctgf conditional mouse knockouts. The hepatocyte-specific Ccn2/Ctgf knockouts (KO) in … WebConnective tissue growth factor (CTGF) plays a critical role in the hepatic stellate cells (HSCs)-mediated development of hepatic fibrosis. Nevertheless, the effects of CTGF …
WebDec 5, 2024 · These observations demonstrate conserved cross-species functions of Ccn2/Ctgf protein in rodent livers. This protein can be induced in hepatocytes and … WebMar 20, 2024 · Liver fibrosis (LF) is caused by chronic liver injury from various causes, such as viral infections, alcohol consumption, non-alcoholic fatty liver disease (NAFLD), …
WebAug 22, 2024 · Accordingly, hepatic fibrosis occurs when liver is repeatedly and continuously injured. Damage to hepatocytes triggers the release of reactive oxygen species (ROS) and inflammatory mediators, which would stimulate carcinogenic process . Untreated fibrosis may progress to liver cirrhosis, leading to organ failure and hepatoma [3,4]. … WebJun 6, 2012 · For example, in liver fibrosis models CTGF is known to increase in response to toxins such as CCl 4 or dimethyl nitrosamine or upon bile duct …
WebNov 5, 2024 · Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and even cancer. ... CTGF, p16, CCL2 and SA-β-gal, ultimately leading to a profibrogenic micro-environment, HSC activation, and enhanced liver fibrosis ... hakko t12-bc2WebAug 6, 2024 · Background: Glomerulonephritis, which causes inflammation in glomeruli, is a common cause of end-stage renal failure. Severe and prolonged inflammation can … hakkotsuWeb氯雷他定是一种h1受体阻滞剂，具有抗炎、抗过敏、抗氧化等药理作用。有研究结果表明，氯雷他定对于急性肝损伤有保护作用 [] ，但评估氯雷他定对于慢性肝损伤造成的肝纤维化的影响报道尚少。 本研究利用脂多糖制备大鼠肝纤维化模型，探究氯雷他定对大鼠肝纤维化的作用及其机制。 pista nutsWebMay 28, 2024 · CTGF is a primary mediator of TGF-β-induced pulmonary fibrosis. CTGF was found to be overexpressed in fibrotic lesions in major organs, including the lung, kidney, liver, skin, cardiovascular system, gastrointestinal system, eye, and gingiva [8]. hakkoudennsiWebConnective Tissue Growth Factor/CCN2. CTGF is a cysteine-rich 40 kDa matricellular growth factor implicated in angiogenesis, wound healing, and development. Although it is … hakko t18-iWebMay 8, 2024 · Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic disorders. … pista nuts uses in tamilWebFeb 7, 2012 · Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4) and in vitro in TGF-beta1-stimulated rat hepatic stellate cell line (HSC-T6). … hakkou