WebThe hepatic clearance is more complex than renal clearance. Like renal clearance, hepatic clearance involves filtering of the blood. Small-molecule drugs, viruses, bacteria or nanoparticles in the blood can be taken up by sinusoidal endothelial cells, hepatocytes, and Kupffer cells in the liver (Zhang et al., 2016). Kupffer cells and ... WebBackground: While not approved by the Food and Drug Administration for treatment of heparin-induced thrombocytopenia (HIT), except in patients undergoing percutaneous …

Hepatic Clearance - an overview ScienceDirect Topics

Webend-stage renal disease undergoing PCI who received monotherapy with either bivalirudin or unfractionated heparin (UFH) (n=71675). In hospital bleeding and mortality were compared and adjusted using the CathPCI Registry logistic regression models with generalized estimating equations with UFH as the reference. Bivalirudin was used in … WebFeb 1, 2024 · Argatroban need a 75 to 90% dose reduction in patients with impaired liver function, because argatroban is eliminated through liver. But there must be no dose reduction (2 μg/kg/min) in renal failure [27]. Bivalirudin is eliminated through renal pathways so it need adjust dose based on creatinine clearance. simplicity 2731

Anticoagulant Use Among Patients With End-Stage Renal …

WebClearance is reduced approximately 20% in patients with moderate and severe renal impairment and by 80% in dialysis-dependent patients; Bivalirudin is hemodialyzable … WebThe median initial bivalirudin dose to achieve target activated partial thromboplastin time was 0.15 mg/kg/h (range 0.04–0.26 mg/kg/h). Dosing requirements increased by 75–125% when renal replacement was included. Median time on … WebAlthough its clearance is largely organ independent (blood proteases), the kidneys provide approximately 20% of its clearance necessitating dose adjustments with moderate renal … simplicity 2705